From Pills to Injections: Exploring Different Methods of Testosterone Replacement Therapy | Volonte

From Pills to Injections: Exploring Different Methods of Testosterone Replacement Therapy

Middle-aged man looks out window thoughtfully
6 Ways Testosterone Replacement Therapy Changes Your Body
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Middle-aged man looks out window thoughtfully
6 Ways Testosterone Replacement Therapy Changes Your Body
June 1, 2024

From Pills to Injections: Exploring Different Methods of Testosterone Replacement Therapy

Testosterone replacement therapy (TRT) has become an essential treatment for many men experiencing the symptoms of low testosterone, such as fatigue, reduced libido, and mood changes. However, with all the methods available, it can be overwhelming to know which is best for you.

In this blog, we’ll explore the different methods of testosterone replacement therapy, helping you understand how they work, their pros and cons, and how to determine the best option for your needs. Whether you’re just starting your TRT journey or considering a switch, this comprehensive guide will provide valuable insights to make an informed decision.



Testosterone replacement supplements are pills you can theoretically take to boost your testosterone levels. Unfortunately, no safe oral testosterone supplements are available in the U.S. Although these pills are on the market, their use is highly discouraged due to the significant risk of liver toxicity and failure. Additionally, these pills offer no advantages over other forms of therapy. Consequently, taking testosterone supplement pills is strongly ill-advised.



There are two types of testosterone replacement patches: topical and oral. The topical patch is applied directly to the arm or upper body while the oral patch goes in your mouth, adhering to the upper gums. Both of these need to be applied daily, with the oral patch requiring two applications a day.

While patches are a common form of testosterone replacement therapy, they often cause side effects. A recent study found that nearly 50% of men using the skin patch experienced red, irritated skin, sometimes with blistering. Similarly, the oral patch has been associated with significant pain, irritation, and a bitter taste.


Creams & Gels

Another common method of testosterone replacement therapy is a topical cream or gel, applied once daily to the arms or upper body. These products allow testosterone to be absorbed directly through the skin.

However, a significant number of men do not absorb the product well and see little to no benefit. Even for those who do respond, noticeable results typically take a month or two of daily use. There are also several risks associated with these treatments.

Absorption can be affected by factors such as dehydration, illness, cold temperatures, or skin irregularities, making the therapy less effective. Additionally, there is a risk of the gel or cream coming into contact with women and children, which can cause serious side effects, including premature puberty in children and hormonal imbalances in both women and children.


Pellet Therapy

One of the most effective methods of testosterone replacement therapy is testosterone pellet therapy. In this form of therapy, a doctor implants small pellets into the subcutaneous layer of the skin, typically in the upper hip or glutes. These pellets, about the size of a grain of rice, contain crystallized testosterone that releases a low dose of the hormone over three to six months.

The procedure involves cleaning the implantation area, administering a local anesthetic, and making a small incision. The doctor then uses a trocar to insert around ten pellets, which provide a steady dose of testosterone until the next implant. A doctor will work with you to determine the right dosage and treatment plan.

It’s crucial to work with a testosterone therapy professional to establish the correct dosage. Your doctor might recommend starting with another form of testosterone replacement, like injections, to determine the right dosage before switching to pellet implants. This approach helps avoid increasing red blood cell count or raising testosterone levels too high.

This form of testosterone therapy is a great option for men with busy schedules as it involves convenient, quick visits only every three months.


Injection Therapy

Testosterone injections are one of the safest and most reliable methods of testosterone replacement therapy. Your physician might recommend starting with injections before switching to pellet implants to help determine the right dosage to relieve low testosterone symptoms without increasing your red blood cell count.

Each week, your doctor will inject the hormone into your muscles, usually the gluteal muscles. Since the testosterone is administered directly into your bloodstream, it releases slowly, allowing your body to absorb it properly.

Weekly testosterone injections are quick, easy, and effective. Although weekly injections might initially seem challenging, the regularity of the doses leads to visible results with minimal fluctuations in physical and mental wellness. Your doctor can administer the injections in 10 minutes or less.

The consistent dosage of testosterone injections helps maintain higher testosterone levels without extreme variations, reducing the chances of mood swings or physical health changes. Over time, testosterone levels will gradually increase with each dose until they return to normal, providing a natural adjustment for your body.


By understanding the different methods of testosterone replacement therapy, you can work with your healthcare provider to tailor a treatment plan that best suits your lifestyle and health goals.

Remember, the goal of TRT is not just to increase testosterone levels but to enhance your quality of life. Stay informed, work with a medical professional, and take proactive steps toward achieving optimal health and vitality.


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Volonte helps men regain their health and well-being through low T testing, testosterone replacement therapy, and weight-loss programs.

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